Detalhe da pesquisa
1.
Efficacy and safety of apremilast in pediatric patients with moderate-to-severe plaque psoriasis: 16-week results from SPROUT, a randomized controlled trial.
J Am Acad Dermatol
; 2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266683
2.
Switchability and minimal effect of food on pharmacokinetics of modified release tablet strengths of omecamtiv mecarbil, a cardiac myosin activator.
Biopharm Drug Dispos
; 42(7): 319-328, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34087948
3.
Efficacy and Pharmacokinetics of Glecaprevir and Pibrentasvir With Concurrent Use of Acid-Reducing Agents in Patients With Chronic HCV Infection.
Clin Gastroenterol Hepatol
; 17(3): 527-535.e6, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012435
4.
Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 2 hepatitis C virus infection.
Hepatology
; 67(2): 505-513, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28865152
5.
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings.
Nat Metab
; 6(2): 290-303, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38316982
6.
Pharmacokinetic assessment of efflux transport in sunitinib distribution to the brain.
J Pharmacol Exp Ther
; 347(3): 755-64, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24113148
7.
Sunitinib LC-MS/MS Assay in Mouse Plasma and Brain Tissue: Application in CNS Distribution Studies.
Chromatographia
; 76(23-24)2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24409000
8.
Pharmacokinetics, Tolerability, and Safety of Glecaprevir/Pibrentasvir Co-formulated Bilayer Tablet Following Repeated Administration in Healthy Chinese Adults.
Clin Pharmacol Drug Dev
; 12(10): 945-955, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37661787
9.
Effect of Omecamtiv Mecarbil on the Pharmacokinetics of Metformin, a Probe Substrate for MATE1/MATE2-K, in Healthy Subjects.
Clin Drug Investig
; 41(7): 647-652, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34097256
10.
Effect of Varying Degrees of Hepatic Impairment on the Pharmacokinetics of Omecamtiv Mecarbil.
Clin Pharmacol Drug Dev
; 10(12): 1442-1451, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34107172
11.
Effect of Varying Degrees of Renal Impairment on the Pharmacokinetics of Omecamtiv Mecarbil.
Clin Pharmacokinet
; 60(8): 1041-1048, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33768487
12.
A Thorough QT Study of the Combination Glecaprevir + Pibrentasvir on Cardiac Repolarization in Healthy Subjects.
Clin Ther
; 42(7): 1317-1329, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32622784
13.
Exposure-Response Relationships for the Efficacy and Safety of Risankizumab in Japanese Subjects with Psoriasis.
Clin Pharmacokinet
; 59(5): 575-589, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31667790
14.
Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials.
J Clin Pharmacol
; 60(3): 331-339, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31515816
15.
A Phase 1 Study to Evaluate the Effect of Crushing, Cutting Into Half, or Grinding of Glecaprevir/Pibrentasvir Tablets on Exposures in Healthy Subjects.
J Pharm Sci
; 107(6): 1724-1730, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29476763
16.
Correction to: Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection.
J Gastroenterol
; 53(5): 689, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29134328
17.
Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection.
J Gastroenterol
; 53(4): 566-575, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29052790
18.
Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 1 hepatitis C virus infection with and without cirrhosis.
J Gastroenterol
; 53(4): 557-565, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28948366
19.
Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma.
Neuro Oncol
; 18(1): 27-36, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26359209
20.
Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma.
Neuro Oncol
; 17(9): 1210-9, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25972455